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KMID : 0364320180430020009
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Journal of East-West Medicine
2018 Volume.43 No. 2 p.9 ~ p.17
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Antibacterial effect of Hwangnyeonhaedok-tang on microorganisms
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Ha Seong-Ho
Park Chung-A
Park Sook-Jahr
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Abstract
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Objective : Hwangnyeonhaedok-tang (HHT) has been used to reduce heat caused by the pathogenic substances and to treat influenza, menopausal syndrome, stomatitis, and toothache. In this study, the effects of HHT on the growth of oral bacteria and acne bacteria were evaluated.
Methods : HHT was prepared by extracting 160 g of dry sample in 2ℓ of water for 3 h. The antibacterial potential of HHT was determined by the agar diffusion method and minimum inhibitory concentration (MIC) assay.
Results : HHT showed strong antibacterial activity against Streptococcus mutan s and Propionibacterium acnes. At the highest amount of HHT tested (2 ㎎/disk), the mean diameter of the clear zone was recorded at 13 ㎜ for S. mutans and 27.5 ㎜ for P. acnes. MIC values for HHT against S. mutans and P. acnes were recorded as 250 and 62.5 ㎍/㎖, respectively. In addition, Phellodendri cortex showed potent antibacterial activity when comparing antimicrobial activity of Scutellariae radix, Coptidis rhizoma and Phellodendri cortex among herbs constituting HHT.
Conclusion : The results of the present study suggest that HHT has antibacterial activity against human pathogenic bacterial strains and indicate possible use of HHT as antibacterial agents.
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KEYWORD
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antibacterial, Hwangnyeonhaedok-tang, S. mutans, P. acnes
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